Nanostructured SBA-15 host: synthesis, characterization and application in ketorolac-tromethamine release system.

Autores
Cussa , jorgelina; Juárez , Juliana María; Gómez Costa, Marcos Bruno; Anunziata , Oscar Alfredo; Anunziata , Oscar Alfredo; Juárez , Juliana María
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión aceptada
Descripción
The ordered mesoporous silica SBA-15 has been applied in studies of ketorolac tromethamine adsorption and release. The SBA-15 materials with hexagonal and regular structure were obtained using a triblock copolymer Pluronic P123 as template and TEOS as a silica source[1]. Drug delivery is an emerging field mainly focused on aiming drugs. The goal of this targeted delivery is to transport an amount of drugs to desirable sites (such as tumors and diseased tissues) while minimizing unwanted side effects of the drugs on other tissues [2]. Controlled drug delivery systems can achieve precise spatial and temporal delivery of therapeutic agents to the target site. Ketorolac tromethamine was adsorbed into SBA-15 silica nanochannels using ethanol as solvent. The physicochemical and textural properties of SBA-15 and ketorolac tromethamine/SBA-15 were characterized by X-ray diffraction, thermogravimetric analysis, transmission electron microscopy, Fourier transform infrared spectroscopy and BET surface studies. Drug release was evaluated by soaking the loaded silica mesoporous material into a solution of HCl (0.1N) at 37 ºC under continuous stirring. Release studies were performed in order to evaluate the required therapeutic efficacy. SBA-15 provides significant improvement in the controlled release of ketorolac tromethamine [3]. In this work, we have shown a promising drug storage material for the effective encapsulation and controlled release of KETO, achieving the required therapeutic efficacy. SBA-15/KETO shows characteristic bands of both, drug materials and the inorganic framework. This indicates that KETO was adsorbed into SBA-15 channel surface without affecting the chemical structure or composition of KETO. The study also demonstrates the storage capacity and release properties of SBA-15 containing KETO. The release of KETO contained in SBA-15 can offer significant improve in controlled drug release and enhance a good analgesia effect.
Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina
Fil: Juárez, Juliana María. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina
Fil: Gómez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina
Fil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina
Materia
SBA-15
Ketorolac tromethamine
Drug controlled release
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Attribution-NonCommercial-NoDerivatives 4.0 International
Repositorio
Repositorio Institucional Abierto (UTN)
Institución
Universidad Tecnológica Nacional
OAI Identificador
oai:ria.utn.edu.ar:20.500.12272/12422
Acceder
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oai_identifier_str oai:ria.utn.edu.ar:20.500.12272/12422
network_acronym_str RIAUTN
repository_id_str a
network_name_str Repositorio Institucional Abierto (UTN)
spelling Nanostructured SBA-15 host: synthesis, characterization and application in ketorolac-tromethamine release system.Cussa , jorgelinaJuárez , Juliana MaríaGómez Costa, Marcos BrunoAnunziata , Oscar AlfredoAnunziata , Oscar AlfredoJuárez , Juliana MaríaSBA-15Ketorolac tromethamineDrug controlled releaseThe ordered mesoporous silica SBA-15 has been applied in studies of ketorolac tromethamine adsorption and release. The SBA-15 materials with hexagonal and regular structure were obtained using a triblock copolymer Pluronic P123 as template and TEOS as a silica source[1]. Drug delivery is an emerging field mainly focused on aiming drugs. The goal of this targeted delivery is to transport an amount of drugs to desirable sites (such as tumors and diseased tissues) while minimizing unwanted side effects of the drugs on other tissues [2]. Controlled drug delivery systems can achieve precise spatial and temporal delivery of therapeutic agents to the target site. Ketorolac tromethamine was adsorbed into SBA-15 silica nanochannels using ethanol as solvent. The physicochemical and textural properties of SBA-15 and ketorolac tromethamine/SBA-15 were characterized by X-ray diffraction, thermogravimetric analysis, transmission electron microscopy, Fourier transform infrared spectroscopy and BET surface studies. Drug release was evaluated by soaking the loaded silica mesoporous material into a solution of HCl (0.1N) at 37 ºC under continuous stirring. Release studies were performed in order to evaluate the required therapeutic efficacy. SBA-15 provides significant improvement in the controlled release of ketorolac tromethamine [3]. In this work, we have shown a promising drug storage material for the effective encapsulation and controlled release of KETO, achieving the required therapeutic efficacy. SBA-15/KETO shows characteristic bands of both, drug materials and the inorganic framework. This indicates that KETO was adsorbed into SBA-15 channel surface without affecting the chemical structure or composition of KETO. The study also demonstrates the storage capacity and release properties of SBA-15 containing KETO. The release of KETO contained in SBA-15 can offer significant improve in controlled drug release and enhance a good analgesia effect.Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; ArgentinaFil: Juárez, Juliana María. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; ArgentinaFil: Gómez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; ArgentinaFil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; ArgentinaUnivesidsad Tecnológica Nacional2025-03-19T20:43:50Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articulopdfapplication/pdfXXV International Materials Research Congress.https://hdl.handle.net/20.500.12272/12422enginfo:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Cussa, Jorgelina; Juárez, Juliana María; Gómez Costa, Marcos Bruno; Anunziata, Oscar Alfredo.https://creativecommons.org/licenses/by-nc-nd/4.0/reponame:Repositorio Institucional Abierto (UTN)instname:Universidad Tecnológica Nacional2026-09-24T12:46:41Zoai:ria.utn.edu.ar:20.500.12272/12422instacron:UTNInstitucionalhttp://ria.utn.edu.ar/Universidad públicaNo correspondehttp://ria.utn.edu.ar/oaigestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2026-09-24 12:46:43.073Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacionalfalse
dc.title.none.fl_str_mv Nanostructured SBA-15 host: synthesis, characterization and application in ketorolac-tromethamine release system.
title Nanostructured SBA-15 host: synthesis, characterization and application in ketorolac-tromethamine release system.
spellingShingle Nanostructured SBA-15 host: synthesis, characterization and application in ketorolac-tromethamine release system.
Cussa , jorgelina
SBA-15
Ketorolac tromethamine
Drug controlled release
title_short Nanostructured SBA-15 host: synthesis, characterization and application in ketorolac-tromethamine release system.
title_full Nanostructured SBA-15 host: synthesis, characterization and application in ketorolac-tromethamine release system.
title_fullStr Nanostructured SBA-15 host: synthesis, characterization and application in ketorolac-tromethamine release system.
title_full_unstemmed Nanostructured SBA-15 host: synthesis, characterization and application in ketorolac-tromethamine release system.
title_sort Nanostructured SBA-15 host: synthesis, characterization and application in ketorolac-tromethamine release system.
dc.creator.none.fl_str_mv Cussa , jorgelina
Juárez , Juliana María
Gómez Costa, Marcos Bruno
Anunziata , Oscar Alfredo
Anunziata , Oscar Alfredo
Juárez , Juliana María
author Cussa , jorgelina
author_facet Cussa , jorgelina
Juárez , Juliana María
Gómez Costa, Marcos Bruno
Anunziata , Oscar Alfredo
author_role author
author2 Juárez , Juliana María
Gómez Costa, Marcos Bruno
Anunziata , Oscar Alfredo
author2_role author
author
author
dc.subject.none.fl_str_mv SBA-15
Ketorolac tromethamine
Drug controlled release
topic SBA-15
Ketorolac tromethamine
Drug controlled release
dc.description.none.fl_txt_mv The ordered mesoporous silica SBA-15 has been applied in studies of ketorolac tromethamine adsorption and release. The SBA-15 materials with hexagonal and regular structure were obtained using a triblock copolymer Pluronic P123 as template and TEOS as a silica source[1]. Drug delivery is an emerging field mainly focused on aiming drugs. The goal of this targeted delivery is to transport an amount of drugs to desirable sites (such as tumors and diseased tissues) while minimizing unwanted side effects of the drugs on other tissues [2]. Controlled drug delivery systems can achieve precise spatial and temporal delivery of therapeutic agents to the target site. Ketorolac tromethamine was adsorbed into SBA-15 silica nanochannels using ethanol as solvent. The physicochemical and textural properties of SBA-15 and ketorolac tromethamine/SBA-15 were characterized by X-ray diffraction, thermogravimetric analysis, transmission electron microscopy, Fourier transform infrared spectroscopy and BET surface studies. Drug release was evaluated by soaking the loaded silica mesoporous material into a solution of HCl (0.1N) at 37 ºC under continuous stirring. Release studies were performed in order to evaluate the required therapeutic efficacy. SBA-15 provides significant improvement in the controlled release of ketorolac tromethamine [3]. In this work, we have shown a promising drug storage material for the effective encapsulation and controlled release of KETO, achieving the required therapeutic efficacy. SBA-15/KETO shows characteristic bands of both, drug materials and the inorganic framework. This indicates that KETO was adsorbed into SBA-15 channel surface without affecting the chemical structure or composition of KETO. The study also demonstrates the storage capacity and release properties of SBA-15 containing KETO. The release of KETO contained in SBA-15 can offer significant improve in controlled drug release and enhance a good analgesia effect.
Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina
Fil: Juárez, Juliana María. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina
Fil: Gómez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina
Fil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina
description The ordered mesoporous silica SBA-15 has been applied in studies of ketorolac tromethamine adsorption and release. The SBA-15 materials with hexagonal and regular structure were obtained using a triblock copolymer Pluronic P123 as template and TEOS as a silica source[1]. Drug delivery is an emerging field mainly focused on aiming drugs. The goal of this targeted delivery is to transport an amount of drugs to desirable sites (such as tumors and diseased tissues) while minimizing unwanted side effects of the drugs on other tissues [2]. Controlled drug delivery systems can achieve precise spatial and temporal delivery of therapeutic agents to the target site. Ketorolac tromethamine was adsorbed into SBA-15 silica nanochannels using ethanol as solvent. The physicochemical and textural properties of SBA-15 and ketorolac tromethamine/SBA-15 were characterized by X-ray diffraction, thermogravimetric analysis, transmission electron microscopy, Fourier transform infrared spectroscopy and BET surface studies. Drug release was evaluated by soaking the loaded silica mesoporous material into a solution of HCl (0.1N) at 37 ºC under continuous stirring. Release studies were performed in order to evaluate the required therapeutic efficacy. SBA-15 provides significant improvement in the controlled release of ketorolac tromethamine [3]. In this work, we have shown a promising drug storage material for the effective encapsulation and controlled release of KETO, achieving the required therapeutic efficacy. SBA-15/KETO shows characteristic bands of both, drug materials and the inorganic framework. This indicates that KETO was adsorbed into SBA-15 channel surface without affecting the chemical structure or composition of KETO. The study also demonstrates the storage capacity and release properties of SBA-15 containing KETO. The release of KETO contained in SBA-15 can offer significant improve in controlled drug release and enhance a good analgesia effect.
publishDate 2016
dc.date.none.fl_str_mv 2016
2025-03-19T20:43:50Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv XXV International Materials Research Congress.
https://hdl.handle.net/20.500.12272/12422
identifier_str_mv XXV International Materials Research Congress.
url https://hdl.handle.net/20.500.12272/12422
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
Cussa, Jorgelina; Juárez, Juliana María; Gómez Costa, Marcos Bruno; Anunziata, Oscar Alfredo.
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
Cussa, Jorgelina; Juárez, Juliana María; Gómez Costa, Marcos Bruno; Anunziata, Oscar Alfredo.
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv pdf
application/pdf
dc.publisher.none.fl_str_mv Univesidsad Tecnológica Nacional
publisher.none.fl_str_mv Univesidsad Tecnológica Nacional
dc.source.none.fl_str_mv reponame:Repositorio Institucional Abierto (UTN)
instname:Universidad Tecnológica Nacional
reponame_str Repositorio Institucional Abierto (UTN)
collection Repositorio Institucional Abierto (UTN)
instname_str Universidad Tecnológica Nacional
repository.name.fl_str_mv Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacional
repository.mail.fl_str_mv gestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.ar
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score 13.265058

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