Controlled drug release system: cyclophosphamide delivery contained in LP-SBA-15 functionalized with terbutylamine.

Autores
Cussa, jorgelina; Juárez , Juliana María; Gómez Costa, Marcos Bruno; Anunziata , Oscar Alfredo; Anunziata , Oscar Alfredo; Juárez , Juliana María
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión aceptada
Descripción
Controlled drug administration systems can keep the level of drugs in specific locations in the organism with low toxicity and above the optimal level. We suggest the LP-SBA15 material as a auspicious new host for drug delivery systems because of its low toxicity high biocompatibility and in vivo biodegradability. LP-SBA-15 materials were synthesized and functionalized using 0-15-30% of tert-butylamine (TBA) and used as effective drug delivery systems. The anticancer drug Cyclophosphamide (CP) is an alkylating compound which is a phosphoramide derivative and is habitually used in autoimmune diseases. Reactive oxygen species production has been related to the mechanism of CP-induced cell death or tumor cell killing. The activated metabolites of CP are released in both healthy and tumor tissues and destroy the cellular DNA and proteins as well as mitochondrial and lysosomal membranes. CP was loaded into the nanomaterial of the transporters and characterized by XRD, FTIR, TGA, TEM and texture, determining the adsorption capacity and its release. The release of the drug was studied for each material by simulating the physiological conditions and submerging the composite, at 37 °C with constant stirring, in a HCl solution (0.1 M) for the first two hours and in Buffer solution pH = 7 the following hours to simulate the conditions of the organism. Release experiment were conducted to determine the requisite efficacy of treatment. The study was performed by UV-Vis spectrophotometry to evaluate the amount of CP released. The mechanism of drug release from the LP-SBA-15 matrix was evaluated by adjusting the experimental data, being the Ritger-Peppas. The promising results we obtained for the controlled release of the drug in a controlled manner using the new material, reaching a quick initial release rate and maintaining a constant rate at high moments, allow us to keep the concentration of the drug in the therapeutic efficacy range, applying it to a great extent to the treatment of diseases that require a rapid response. Lastly, it was suggested that the LP-SBA-15 nanomaterial functionalized with 15% TBA was the most desirable system due to they had adequate amounts of both drug loading and release.
Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Juárez, Juliana María. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Gómez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Materia
LP-SBA-15
Cyclophosphamide
Nanostructured host
Drug delivering device
Nanoscale medicine
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Attribution-NonCommercial-NoDerivatives 4.0 International
Repositorio
Repositorio Institucional Abierto (UTN)
Institución
Universidad Tecnológica Nacional
OAI Identificador
oai:ria.utn.edu.ar:20.500.12272/12690
Acceder
id RIAUTN_837a4a611234364812a29516bb34c6a6
oai_identifier_str oai:ria.utn.edu.ar:20.500.12272/12690
network_acronym_str RIAUTN
repository_id_str a
network_name_str Repositorio Institucional Abierto (UTN)
spelling Controlled drug release system: cyclophosphamide delivery contained in LP-SBA-15 functionalized with terbutylamine.Cussa, jorgelinaJuárez , Juliana MaríaGómez Costa, Marcos BrunoAnunziata , Oscar AlfredoAnunziata , Oscar AlfredoJuárez , Juliana MaríaLP-SBA-15CyclophosphamideNanostructured hostDrug delivering deviceNanoscale medicineControlled drug administration systems can keep the level of drugs in specific locations in the organism with low toxicity and above the optimal level. We suggest the LP-SBA15 material as a auspicious new host for drug delivery systems because of its low toxicity high biocompatibility and in vivo biodegradability. LP-SBA-15 materials were synthesized and functionalized using 0-15-30% of tert-butylamine (TBA) and used as effective drug delivery systems. The anticancer drug Cyclophosphamide (CP) is an alkylating compound which is a phosphoramide derivative and is habitually used in autoimmune diseases. Reactive oxygen species production has been related to the mechanism of CP-induced cell death or tumor cell killing. The activated metabolites of CP are released in both healthy and tumor tissues and destroy the cellular DNA and proteins as well as mitochondrial and lysosomal membranes. CP was loaded into the nanomaterial of the transporters and characterized by XRD, FTIR, TGA, TEM and texture, determining the adsorption capacity and its release. The release of the drug was studied for each material by simulating the physiological conditions and submerging the composite, at 37 °C with constant stirring, in a HCl solution (0.1 M) for the first two hours and in Buffer solution pH = 7 the following hours to simulate the conditions of the organism. Release experiment were conducted to determine the requisite efficacy of treatment. The study was performed by UV-Vis spectrophotometry to evaluate the amount of CP released. The mechanism of drug release from the LP-SBA-15 matrix was evaluated by adjusting the experimental data, being the Ritger-Peppas. The promising results we obtained for the controlled release of the drug in a controlled manner using the new material, reaching a quick initial release rate and maintaining a constant rate at high moments, allow us to keep the concentration of the drug in the therapeutic efficacy range, applying it to a great extent to the treatment of diseases that require a rapid response. Lastly, it was suggested that the LP-SBA-15 nanomaterial functionalized with 15% TBA was the most desirable system due to they had adequate amounts of both drug loading and release.Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.Fil: Juárez, Juliana María. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.Fil: Gómez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.Fil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.Univesidsad Tecnológica Nacional.2025-04-14T19:44:10Z2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articulopdfapplication/pdfInternational materials research congress, 2023.https://hdl.handle.net/20.500.12272/12690enginfo:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Cussa, Jorgelina; Juárez, Juliana María; Gómez Costa, Marcos Bruno; Anunziata, Oscar Alfredo.https://creativecommons.org/licenses/by-nc-nd/4.0/reponame:Repositorio Institucional Abierto (UTN)instname:Universidad Tecnológica Nacional2026-10-01T12:00:01Zoai:ria.utn.edu.ar:20.500.12272/12690instacron:UTNInstitucionalhttp://ria.utn.edu.ar/Universidad públicaNo correspondehttp://ria.utn.edu.ar/oaigestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2026-10-01 12:00:02.577Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacionalfalse
dc.title.none.fl_str_mv Controlled drug release system: cyclophosphamide delivery contained in LP-SBA-15 functionalized with terbutylamine.
title Controlled drug release system: cyclophosphamide delivery contained in LP-SBA-15 functionalized with terbutylamine.
spellingShingle Controlled drug release system: cyclophosphamide delivery contained in LP-SBA-15 functionalized with terbutylamine.
Cussa, jorgelina
LP-SBA-15
Cyclophosphamide
Nanostructured host
Drug delivering device
Nanoscale medicine
title_short Controlled drug release system: cyclophosphamide delivery contained in LP-SBA-15 functionalized with terbutylamine.
title_full Controlled drug release system: cyclophosphamide delivery contained in LP-SBA-15 functionalized with terbutylamine.
title_fullStr Controlled drug release system: cyclophosphamide delivery contained in LP-SBA-15 functionalized with terbutylamine.
title_full_unstemmed Controlled drug release system: cyclophosphamide delivery contained in LP-SBA-15 functionalized with terbutylamine.
title_sort Controlled drug release system: cyclophosphamide delivery contained in LP-SBA-15 functionalized with terbutylamine.
dc.creator.none.fl_str_mv Cussa, jorgelina
Juárez , Juliana María
Gómez Costa, Marcos Bruno
Anunziata , Oscar Alfredo
Anunziata , Oscar Alfredo
Juárez , Juliana María
author Cussa, jorgelina
author_facet Cussa, jorgelina
Juárez , Juliana María
Gómez Costa, Marcos Bruno
Anunziata , Oscar Alfredo
author_role author
author2 Juárez , Juliana María
Gómez Costa, Marcos Bruno
Anunziata , Oscar Alfredo
author2_role author
author
author
dc.subject.none.fl_str_mv LP-SBA-15
Cyclophosphamide
Nanostructured host
Drug delivering device
Nanoscale medicine
topic LP-SBA-15
Cyclophosphamide
Nanostructured host
Drug delivering device
Nanoscale medicine
dc.description.none.fl_txt_mv Controlled drug administration systems can keep the level of drugs in specific locations in the organism with low toxicity and above the optimal level. We suggest the LP-SBA15 material as a auspicious new host for drug delivery systems because of its low toxicity high biocompatibility and in vivo biodegradability. LP-SBA-15 materials were synthesized and functionalized using 0-15-30% of tert-butylamine (TBA) and used as effective drug delivery systems. The anticancer drug Cyclophosphamide (CP) is an alkylating compound which is a phosphoramide derivative and is habitually used in autoimmune diseases. Reactive oxygen species production has been related to the mechanism of CP-induced cell death or tumor cell killing. The activated metabolites of CP are released in both healthy and tumor tissues and destroy the cellular DNA and proteins as well as mitochondrial and lysosomal membranes. CP was loaded into the nanomaterial of the transporters and characterized by XRD, FTIR, TGA, TEM and texture, determining the adsorption capacity and its release. The release of the drug was studied for each material by simulating the physiological conditions and submerging the composite, at 37 °C with constant stirring, in a HCl solution (0.1 M) for the first two hours and in Buffer solution pH = 7 the following hours to simulate the conditions of the organism. Release experiment were conducted to determine the requisite efficacy of treatment. The study was performed by UV-Vis spectrophotometry to evaluate the amount of CP released. The mechanism of drug release from the LP-SBA-15 matrix was evaluated by adjusting the experimental data, being the Ritger-Peppas. The promising results we obtained for the controlled release of the drug in a controlled manner using the new material, reaching a quick initial release rate and maintaining a constant rate at high moments, allow us to keep the concentration of the drug in the therapeutic efficacy range, applying it to a great extent to the treatment of diseases that require a rapid response. Lastly, it was suggested that the LP-SBA-15 nanomaterial functionalized with 15% TBA was the most desirable system due to they had adequate amounts of both drug loading and release.
Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Juárez, Juliana María. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Gómez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
description Controlled drug administration systems can keep the level of drugs in specific locations in the organism with low toxicity and above the optimal level. We suggest the LP-SBA15 material as a auspicious new host for drug delivery systems because of its low toxicity high biocompatibility and in vivo biodegradability. LP-SBA-15 materials were synthesized and functionalized using 0-15-30% of tert-butylamine (TBA) and used as effective drug delivery systems. The anticancer drug Cyclophosphamide (CP) is an alkylating compound which is a phosphoramide derivative and is habitually used in autoimmune diseases. Reactive oxygen species production has been related to the mechanism of CP-induced cell death or tumor cell killing. The activated metabolites of CP are released in both healthy and tumor tissues and destroy the cellular DNA and proteins as well as mitochondrial and lysosomal membranes. CP was loaded into the nanomaterial of the transporters and characterized by XRD, FTIR, TGA, TEM and texture, determining the adsorption capacity and its release. The release of the drug was studied for each material by simulating the physiological conditions and submerging the composite, at 37 °C with constant stirring, in a HCl solution (0.1 M) for the first two hours and in Buffer solution pH = 7 the following hours to simulate the conditions of the organism. Release experiment were conducted to determine the requisite efficacy of treatment. The study was performed by UV-Vis spectrophotometry to evaluate the amount of CP released. The mechanism of drug release from the LP-SBA-15 matrix was evaluated by adjusting the experimental data, being the Ritger-Peppas. The promising results we obtained for the controlled release of the drug in a controlled manner using the new material, reaching a quick initial release rate and maintaining a constant rate at high moments, allow us to keep the concentration of the drug in the therapeutic efficacy range, applying it to a great extent to the treatment of diseases that require a rapid response. Lastly, it was suggested that the LP-SBA-15 nanomaterial functionalized with 15% TBA was the most desirable system due to they had adequate amounts of both drug loading and release.
publishDate 2023
dc.date.none.fl_str_mv 2023
2025-04-14T19:44:10Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv International materials research congress, 2023.
https://hdl.handle.net/20.500.12272/12690
identifier_str_mv International materials research congress, 2023.
url https://hdl.handle.net/20.500.12272/12690
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
Cussa, Jorgelina; Juárez, Juliana María; Gómez Costa, Marcos Bruno; Anunziata, Oscar Alfredo.
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
Cussa, Jorgelina; Juárez, Juliana María; Gómez Costa, Marcos Bruno; Anunziata, Oscar Alfredo.
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv pdf
application/pdf
dc.publisher.none.fl_str_mv Univesidsad Tecnológica Nacional.
publisher.none.fl_str_mv Univesidsad Tecnológica Nacional.
dc.source.none.fl_str_mv reponame:Repositorio Institucional Abierto (UTN)
instname:Universidad Tecnológica Nacional
reponame_str Repositorio Institucional Abierto (UTN)
collection Repositorio Institucional Abierto (UTN)
instname_str Universidad Tecnológica Nacional
repository.name.fl_str_mv Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacional
repository.mail.fl_str_mv gestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.ar
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score 13.365483

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