Large pore SBA-15 functionalized as drug carrier of Cyclophosphamide.

Autores
Juárez , Juliana María; Cussa, Jorgelina; Anunziata, Oscar Alfredo; Gómez Costa, Marcos Bruno
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión aceptada
Descripción
Controlled drug administration systems can keep the level of drugs in specific locations in the organism with low toxicity and above the optimal level. We suggest the LP-SBA-15 material as an auspicious new host for drug delivery systems because of its low toxicity high biocompatibility and in vivo biodegradability. LP-SBA-15 materials were synthesized and functionalized using 0-15-30% of tert-butylamine (TBA) and used as effective drug delivery systems. The anticancer drug Cyclophosphamide (CP) is an alkylating compound which is a phosphoramide derivative and is habitually used in autoimmune diseases. Reactive oxygen species production has been related to the mechanism of CP-induced cell death or tumor cell killing. The activated metabolites of CP are released in both healthy and tumor tissues and destroy the cellular DNA and proteins as well as mitochondrial and lysosomal membranes. CP was loaded into the nanomaterial of the transporters and characterized by N2 adsorption-desorption, Ultraviolet-visible diffusereflectance spectroscopy (UV-Vis DRS), FTIR, determining the adsorption capacity and its release. The release of the drug was studied for each material by simulating the physiological conditions and submerging the composite, at 37 °C with constant stirring, in a HCl solution (0.1 M) for the first two hours and in Buffer solution pH = 7 the following hours to simulate the conditions of the organism. Release experiments were conducted to determine the requisite efficacy of treatment. The study was performed by UV-Vis spectrophotometry to evaluate the amount of CP released. The mechanism of drug release from the LP-SBA-15 functionalized matrix was evaluated by adjusting the experimental data, being the Ritger-Peppas model, Weibull model and First-Order model, the best models to adjust the experimental data is the, which is confirmed by the R2 coefficient of determination. The promising results we obtained for the controlled release of the drug in a controlled manner using the new material, reaching a quick initial release rate and maintaining a constant rate at high moments, allow us to keep the concentration of the drug in the therapeutic efficacy range, applying itto a great extent to the treatment of diseases that require a rapid response. Lastly, it was suggested thatthe LP SBA-15 nanomaterial functionalized with 15% TBA was the most desirable system due to they had adequate amounts of both drug loading and release
Fil: Juárez, Juliana María. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Gómez costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Materia
LP-SBA-15
Tert-butylamine
Cyclophosphamide
Nanostructured
Host
Drug delivering device
Nanoscale medicine
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Attribution-NonCommercial-NoDerivatives 4.0 International
Repositorio
Repositorio Institucional Abierto (UTN)
Institución
Universidad Tecnológica Nacional
OAI Identificador
oai:ria.utn.edu.ar:20.500.12272/12278
Acceder
id RIAUTN_d4dc436d6344473dabc4a7c7abe218be
oai_identifier_str oai:ria.utn.edu.ar:20.500.12272/12278
network_acronym_str RIAUTN
repository_id_str a
network_name_str Repositorio Institucional Abierto (UTN)
spelling Large pore SBA-15 functionalized as drug carrier of Cyclophosphamide.Juárez , Juliana MaríaCussa, JorgelinaAnunziata, Oscar AlfredoGómez Costa, Marcos BrunoLP-SBA-15Tert-butylamineCyclophosphamideNanostructuredHostDrug delivering deviceNanoscale medicineControlled drug administration systems can keep the level of drugs in specific locations in the organism with low toxicity and above the optimal level. We suggest the LP-SBA-15 material as an auspicious new host for drug delivery systems because of its low toxicity high biocompatibility and in vivo biodegradability. LP-SBA-15 materials were synthesized and functionalized using 0-15-30% of tert-butylamine (TBA) and used as effective drug delivery systems. The anticancer drug Cyclophosphamide (CP) is an alkylating compound which is a phosphoramide derivative and is habitually used in autoimmune diseases. Reactive oxygen species production has been related to the mechanism of CP-induced cell death or tumor cell killing. The activated metabolites of CP are released in both healthy and tumor tissues and destroy the cellular DNA and proteins as well as mitochondrial and lysosomal membranes. CP was loaded into the nanomaterial of the transporters and characterized by N2 adsorption-desorption, Ultraviolet-visible diffusereflectance spectroscopy (UV-Vis DRS), FTIR, determining the adsorption capacity and its release. The release of the drug was studied for each material by simulating the physiological conditions and submerging the composite, at 37 °C with constant stirring, in a HCl solution (0.1 M) for the first two hours and in Buffer solution pH = 7 the following hours to simulate the conditions of the organism. Release experiments were conducted to determine the requisite efficacy of treatment. The study was performed by UV-Vis spectrophotometry to evaluate the amount of CP released. The mechanism of drug release from the LP-SBA-15 functionalized matrix was evaluated by adjusting the experimental data, being the Ritger-Peppas model, Weibull model and First-Order model, the best models to adjust the experimental data is the, which is confirmed by the R2 coefficient of determination. The promising results we obtained for the controlled release of the drug in a controlled manner using the new material, reaching a quick initial release rate and maintaining a constant rate at high moments, allow us to keep the concentration of the drug in the therapeutic efficacy range, applying itto a great extent to the treatment of diseases that require a rapid response. Lastly, it was suggested thatthe LP SBA-15 nanomaterial functionalized with 15% TBA was the most desirable system due to they had adequate amounts of both drug loading and releaseFil: Juárez, Juliana María. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.Fil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.Fil: Gómez costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.Univesidsad Tecnológica Nacional2025-02-28T19:50:52Z2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articulopdfapplication/pdf12th International Conference on Advanced Materials and Engineering Materials 2023.http://hdl.handle.net/20.500.12272/12278enginfo:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Juárez, Juliana María; Cussa, Jorgelina; Anunziata, Oscar Alfredo; Gómez Costa, Marcos Bruno.https://creativecommons.org/licenses/by-nc-nd/4.0/reponame:Repositorio Institucional Abierto (UTN)instname:Universidad Tecnológica Nacional2026-09-24T12:44:41Zoai:ria.utn.edu.ar:20.500.12272/12278instacron:UTNInstitucionalhttp://ria.utn.edu.ar/Universidad públicaNo correspondehttp://ria.utn.edu.ar/oaigestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2026-09-24 12:44:43.274Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacionalfalse
dc.title.none.fl_str_mv Large pore SBA-15 functionalized as drug carrier of Cyclophosphamide.
title Large pore SBA-15 functionalized as drug carrier of Cyclophosphamide.
spellingShingle Large pore SBA-15 functionalized as drug carrier of Cyclophosphamide.
Juárez , Juliana María
LP-SBA-15
Tert-butylamine
Cyclophosphamide
Nanostructured
Host
Drug delivering device
Nanoscale medicine
title_short Large pore SBA-15 functionalized as drug carrier of Cyclophosphamide.
title_full Large pore SBA-15 functionalized as drug carrier of Cyclophosphamide.
title_fullStr Large pore SBA-15 functionalized as drug carrier of Cyclophosphamide.
title_full_unstemmed Large pore SBA-15 functionalized as drug carrier of Cyclophosphamide.
title_sort Large pore SBA-15 functionalized as drug carrier of Cyclophosphamide.
dc.creator.none.fl_str_mv Juárez , Juliana María
Cussa, Jorgelina
Anunziata, Oscar Alfredo
Gómez Costa, Marcos Bruno
author Juárez , Juliana María
author_facet Juárez , Juliana María
Cussa, Jorgelina
Anunziata, Oscar Alfredo
Gómez Costa, Marcos Bruno
author_role author
author2 Cussa, Jorgelina
Anunziata, Oscar Alfredo
Gómez Costa, Marcos Bruno
author2_role author
author
author
dc.subject.none.fl_str_mv LP-SBA-15
Tert-butylamine
Cyclophosphamide
Nanostructured
Host
Drug delivering device
Nanoscale medicine
topic LP-SBA-15
Tert-butylamine
Cyclophosphamide
Nanostructured
Host
Drug delivering device
Nanoscale medicine
dc.description.none.fl_txt_mv Controlled drug administration systems can keep the level of drugs in specific locations in the organism with low toxicity and above the optimal level. We suggest the LP-SBA-15 material as an auspicious new host for drug delivery systems because of its low toxicity high biocompatibility and in vivo biodegradability. LP-SBA-15 materials were synthesized and functionalized using 0-15-30% of tert-butylamine (TBA) and used as effective drug delivery systems. The anticancer drug Cyclophosphamide (CP) is an alkylating compound which is a phosphoramide derivative and is habitually used in autoimmune diseases. Reactive oxygen species production has been related to the mechanism of CP-induced cell death or tumor cell killing. The activated metabolites of CP are released in both healthy and tumor tissues and destroy the cellular DNA and proteins as well as mitochondrial and lysosomal membranes. CP was loaded into the nanomaterial of the transporters and characterized by N2 adsorption-desorption, Ultraviolet-visible diffusereflectance spectroscopy (UV-Vis DRS), FTIR, determining the adsorption capacity and its release. The release of the drug was studied for each material by simulating the physiological conditions and submerging the composite, at 37 °C with constant stirring, in a HCl solution (0.1 M) for the first two hours and in Buffer solution pH = 7 the following hours to simulate the conditions of the organism. Release experiments were conducted to determine the requisite efficacy of treatment. The study was performed by UV-Vis spectrophotometry to evaluate the amount of CP released. The mechanism of drug release from the LP-SBA-15 functionalized matrix was evaluated by adjusting the experimental data, being the Ritger-Peppas model, Weibull model and First-Order model, the best models to adjust the experimental data is the, which is confirmed by the R2 coefficient of determination. The promising results we obtained for the controlled release of the drug in a controlled manner using the new material, reaching a quick initial release rate and maintaining a constant rate at high moments, allow us to keep the concentration of the drug in the therapeutic efficacy range, applying itto a great extent to the treatment of diseases that require a rapid response. Lastly, it was suggested thatthe LP SBA-15 nanomaterial functionalized with 15% TBA was the most desirable system due to they had adequate amounts of both drug loading and release
Fil: Juárez, Juliana María. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Gómez costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
description Controlled drug administration systems can keep the level of drugs in specific locations in the organism with low toxicity and above the optimal level. We suggest the LP-SBA-15 material as an auspicious new host for drug delivery systems because of its low toxicity high biocompatibility and in vivo biodegradability. LP-SBA-15 materials were synthesized and functionalized using 0-15-30% of tert-butylamine (TBA) and used as effective drug delivery systems. The anticancer drug Cyclophosphamide (CP) is an alkylating compound which is a phosphoramide derivative and is habitually used in autoimmune diseases. Reactive oxygen species production has been related to the mechanism of CP-induced cell death or tumor cell killing. The activated metabolites of CP are released in both healthy and tumor tissues and destroy the cellular DNA and proteins as well as mitochondrial and lysosomal membranes. CP was loaded into the nanomaterial of the transporters and characterized by N2 adsorption-desorption, Ultraviolet-visible diffusereflectance spectroscopy (UV-Vis DRS), FTIR, determining the adsorption capacity and its release. The release of the drug was studied for each material by simulating the physiological conditions and submerging the composite, at 37 °C with constant stirring, in a HCl solution (0.1 M) for the first two hours and in Buffer solution pH = 7 the following hours to simulate the conditions of the organism. Release experiments were conducted to determine the requisite efficacy of treatment. The study was performed by UV-Vis spectrophotometry to evaluate the amount of CP released. The mechanism of drug release from the LP-SBA-15 functionalized matrix was evaluated by adjusting the experimental data, being the Ritger-Peppas model, Weibull model and First-Order model, the best models to adjust the experimental data is the, which is confirmed by the R2 coefficient of determination. The promising results we obtained for the controlled release of the drug in a controlled manner using the new material, reaching a quick initial release rate and maintaining a constant rate at high moments, allow us to keep the concentration of the drug in the therapeutic efficacy range, applying itto a great extent to the treatment of diseases that require a rapid response. Lastly, it was suggested thatthe LP SBA-15 nanomaterial functionalized with 15% TBA was the most desirable system due to they had adequate amounts of both drug loading and release
publishDate 2023
dc.date.none.fl_str_mv 2023
2025-02-28T19:50:52Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv 12th International Conference on Advanced Materials and Engineering Materials 2023.
http://hdl.handle.net/20.500.12272/12278
identifier_str_mv 12th International Conference on Advanced Materials and Engineering Materials 2023.
url http://hdl.handle.net/20.500.12272/12278
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
Juárez, Juliana María; Cussa, Jorgelina; Anunziata, Oscar Alfredo; Gómez Costa, Marcos Bruno.
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
Juárez, Juliana María; Cussa, Jorgelina; Anunziata, Oscar Alfredo; Gómez Costa, Marcos Bruno.
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv pdf
application/pdf
dc.publisher.none.fl_str_mv Univesidsad Tecnológica Nacional
publisher.none.fl_str_mv Univesidsad Tecnológica Nacional
dc.source.none.fl_str_mv reponame:Repositorio Institucional Abierto (UTN)
instname:Universidad Tecnológica Nacional
reponame_str Repositorio Institucional Abierto (UTN)
collection Repositorio Institucional Abierto (UTN)
instname_str Universidad Tecnológica Nacional
repository.name.fl_str_mv Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacional
repository.mail.fl_str_mv gestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.ar
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score 13.265058

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