Successful controlled release of cyclophosphamide from tertbutylamine-functionalized large-pore SBA-15

Autores
Cussa , jorgelina; Juárez, Juliana; Gómez Costa, Marcos Bruno; Anunziata , Oscar Alfredo
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión aceptada
Descripción
Controlled drug delivery systems operate effectively using the correct carrier/host design that respects the physicochemical characteristics of the drug. LP-SBA-15 shows exceptional qualities as a new host for cyclophosphamide (CP) delivery due to its low toxicity, high biocompatibility, and biodegradability in vivo. Cyclophosphamide is a phosphoramide-derived alkylating compound currently used for treating autoimmune diseases and slowing or restraining cancer cell growth. LP-SBA-15 was synthesized and functionalized using 0%–15%–25% tert-Butylamine (TBA) to incorporate the drug. The composite was characterized by XRD, N2 physisorption, UV-VIS, and FTIR spectroscopy. Absorption and release of CP were assessed by UV- VIS spectrophotometry. The release mechanism from the functionalized LP-SBA-15 matrix was evaluated by fitting experimental data with different mathematical models. The Ritger – Peppas, Weibull, and First-Order models were the most appropriate, as confirmed by the coefficient of determination R2 and other statistics. We designed LP SBA-15 functio nalized with 15% TBA as a suitable system that achieves a moderate initial release rate and maintains a constant rate over long periods, enabling the nanodrug (CP) to concentrate on tumor tissue and not on normal cells while simultaneously reaching adequate levels over time and avoiding harmful side effects due to their deposition.
Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Juárez, Juliana. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Gómez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Peer Reviewed
Materia
Large-pore SBA-15
Functionalized
Tert-butylamine
Cyclophosphamide
Efficiently delivered antineoplastic drug
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Attribution-NonCommercial-NoDerivs 2.5 Argentina
Repositorio
Repositorio Institucional Abierto (UTN)
Institución
Universidad Tecnológica Nacional
OAI Identificador
oai:ria.utn.edu.ar:20.500.12272/15380
Acceder
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network_acronym_str RIAUTN
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network_name_str Repositorio Institucional Abierto (UTN)
spelling Successful controlled release of cyclophosphamide from tertbutylamine-functionalized large-pore SBA-15Cussa , jorgelinaJuárez, JulianaGómez Costa, Marcos BrunoAnunziata , Oscar AlfredoLarge-pore SBA-15FunctionalizedTert-butylamineCyclophosphamideEfficiently delivered antineoplastic drugControlled drug delivery systems operate effectively using the correct carrier/host design that respects the physicochemical characteristics of the drug. LP-SBA-15 shows exceptional qualities as a new host for cyclophosphamide (CP) delivery due to its low toxicity, high biocompatibility, and biodegradability in vivo. Cyclophosphamide is a phosphoramide-derived alkylating compound currently used for treating autoimmune diseases and slowing or restraining cancer cell growth. LP-SBA-15 was synthesized and functionalized using 0%–15%–25% tert-Butylamine (TBA) to incorporate the drug. The composite was characterized by XRD, N2 physisorption, UV-VIS, and FTIR spectroscopy. Absorption and release of CP were assessed by UV- VIS spectrophotometry. The release mechanism from the functionalized LP-SBA-15 matrix was evaluated by fitting experimental data with different mathematical models. The Ritger – Peppas, Weibull, and First-Order models were the most appropriate, as confirmed by the coefficient of determination R2 and other statistics. We designed LP SBA-15 functio nalized with 15% TBA as a suitable system that achieves a moderate initial release rate and maintains a constant rate over long periods, enabling the nanodrug (CP) to concentrate on tumor tissue and not on normal cells while simultaneously reaching adequate levels over time and avoiding harmful side effects due to their deposition.Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.Fil: Juárez, Juliana. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.Fil: Gómez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.Fil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.Peer ReviewedTaylor y Francis2026-08-11T20:00:53Z2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articulopdfapplication/pdfComposite Interfaceshttps://hdl.handle.net/20.500.12272/15380https://doi.org/10.1080/09276440.2024.2331329enginfo:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivs 2.5 Argentinahttp://creativecommons.org/licenses/by-nc-nd/2.5/ar/Cussa, Jorgelina; Juárez, Juliana; Gómez Costa, Marcos Bruno; Anunziata, Oscar Alfredo.https://creativecommons.org/licenses/by-nc-nd/4.0/reponame:Repositorio Institucional Abierto (UTN)instname:Universidad Tecnológica Nacional2026-09-24T12:44:13Zoai:ria.utn.edu.ar:20.500.12272/15380instacron:UTNInstitucionalhttp://ria.utn.edu.ar/Universidad públicaNo correspondehttp://ria.utn.edu.ar/oaigestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2026-09-24 12:44:13.868Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacionalfalse
dc.title.none.fl_str_mv Successful controlled release of cyclophosphamide from tertbutylamine-functionalized large-pore SBA-15
title Successful controlled release of cyclophosphamide from tertbutylamine-functionalized large-pore SBA-15
spellingShingle Successful controlled release of cyclophosphamide from tertbutylamine-functionalized large-pore SBA-15
Cussa , jorgelina
Large-pore SBA-15
Functionalized
Tert-butylamine
Cyclophosphamide
Efficiently delivered antineoplastic drug
title_short Successful controlled release of cyclophosphamide from tertbutylamine-functionalized large-pore SBA-15
title_full Successful controlled release of cyclophosphamide from tertbutylamine-functionalized large-pore SBA-15
title_fullStr Successful controlled release of cyclophosphamide from tertbutylamine-functionalized large-pore SBA-15
title_full_unstemmed Successful controlled release of cyclophosphamide from tertbutylamine-functionalized large-pore SBA-15
title_sort Successful controlled release of cyclophosphamide from tertbutylamine-functionalized large-pore SBA-15
dc.creator.none.fl_str_mv Cussa , jorgelina
Juárez, Juliana
Gómez Costa, Marcos Bruno
Anunziata , Oscar Alfredo
author Cussa , jorgelina
author_facet Cussa , jorgelina
Juárez, Juliana
Gómez Costa, Marcos Bruno
Anunziata , Oscar Alfredo
author_role author
author2 Juárez, Juliana
Gómez Costa, Marcos Bruno
Anunziata , Oscar Alfredo
author2_role author
author
author
dc.subject.none.fl_str_mv Large-pore SBA-15
Functionalized
Tert-butylamine
Cyclophosphamide
Efficiently delivered antineoplastic drug
topic Large-pore SBA-15
Functionalized
Tert-butylamine
Cyclophosphamide
Efficiently delivered antineoplastic drug
dc.description.none.fl_txt_mv Controlled drug delivery systems operate effectively using the correct carrier/host design that respects the physicochemical characteristics of the drug. LP-SBA-15 shows exceptional qualities as a new host for cyclophosphamide (CP) delivery due to its low toxicity, high biocompatibility, and biodegradability in vivo. Cyclophosphamide is a phosphoramide-derived alkylating compound currently used for treating autoimmune diseases and slowing or restraining cancer cell growth. LP-SBA-15 was synthesized and functionalized using 0%–15%–25% tert-Butylamine (TBA) to incorporate the drug. The composite was characterized by XRD, N2 physisorption, UV-VIS, and FTIR spectroscopy. Absorption and release of CP were assessed by UV- VIS spectrophotometry. The release mechanism from the functionalized LP-SBA-15 matrix was evaluated by fitting experimental data with different mathematical models. The Ritger – Peppas, Weibull, and First-Order models were the most appropriate, as confirmed by the coefficient of determination R2 and other statistics. We designed LP SBA-15 functio nalized with 15% TBA as a suitable system that achieves a moderate initial release rate and maintains a constant rate over long periods, enabling the nanodrug (CP) to concentrate on tumor tissue and not on normal cells while simultaneously reaching adequate levels over time and avoiding harmful side effects due to their deposition.
Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Juárez, Juliana. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Gómez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Peer Reviewed
description Controlled drug delivery systems operate effectively using the correct carrier/host design that respects the physicochemical characteristics of the drug. LP-SBA-15 shows exceptional qualities as a new host for cyclophosphamide (CP) delivery due to its low toxicity, high biocompatibility, and biodegradability in vivo. Cyclophosphamide is a phosphoramide-derived alkylating compound currently used for treating autoimmune diseases and slowing or restraining cancer cell growth. LP-SBA-15 was synthesized and functionalized using 0%–15%–25% tert-Butylamine (TBA) to incorporate the drug. The composite was characterized by XRD, N2 physisorption, UV-VIS, and FTIR spectroscopy. Absorption and release of CP were assessed by UV- VIS spectrophotometry. The release mechanism from the functionalized LP-SBA-15 matrix was evaluated by fitting experimental data with different mathematical models. The Ritger – Peppas, Weibull, and First-Order models were the most appropriate, as confirmed by the coefficient of determination R2 and other statistics. We designed LP SBA-15 functio nalized with 15% TBA as a suitable system that achieves a moderate initial release rate and maintains a constant rate over long periods, enabling the nanodrug (CP) to concentrate on tumor tissue and not on normal cells while simultaneously reaching adequate levels over time and avoiding harmful side effects due to their deposition.
publishDate 2024
dc.date.none.fl_str_mv 2024
2026-08-11T20:00:53Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv Composite Interfaces
https://hdl.handle.net/20.500.12272/15380
https://doi.org/10.1080/09276440.2024.2331329
identifier_str_mv Composite Interfaces
url https://hdl.handle.net/20.500.12272/15380
https://doi.org/10.1080/09276440.2024.2331329
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivs 2.5 Argentina
http://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Cussa, Jorgelina; Juárez, Juliana; Gómez Costa, Marcos Bruno; Anunziata, Oscar Alfredo.
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivs 2.5 Argentina
http://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Cussa, Jorgelina; Juárez, Juliana; Gómez Costa, Marcos Bruno; Anunziata, Oscar Alfredo.
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor y Francis
publisher.none.fl_str_mv Taylor y Francis
dc.source.none.fl_str_mv reponame:Repositorio Institucional Abierto (UTN)
instname:Universidad Tecnológica Nacional
reponame_str Repositorio Institucional Abierto (UTN)
collection Repositorio Institucional Abierto (UTN)
instname_str Universidad Tecnológica Nacional
repository.name.fl_str_mv Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacional
repository.mail.fl_str_mv gestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.ar
_version_ 1877230873199247360
score 13.265058

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