Functional LP-SBA-15/tert-butylamine nanocarriers for loratadine: synthesis, characterization, and controlled release evaluation

Autores
Juárez, Juliana; Cussa , jorgelina; Gómez Costa, Marcos Bruno
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión aceptada
Descripción
The development of functional mesoporous carriers offers a promising strategy for enhancing the solubility and controlled release of poorly water-soluble drugs. This study aims to design and evaluate tert-butylamine-functionalized large-pore SBA-15 (LP-SBA-15) as an efficient carrier for loratadine (LORA). LP-SBA-15 was synthesized using a micelle-expanding agent and subsequently functionalized with TBA groups. Structural integrity and chemical modifications were confirmed through XRD, TEM, FTIR, and UV–Vis analyses. Nitrogen physisorption was used to assess textural changes after functionalization and drug loading. Drug loading content (DLC) and release profiles were determined spectrophotometrically, and release kinetics were modeled using Ritger–Peppas, Higuchi, and Weibull equations. The mesostructure was preserved after modification, while surface area and pore volume decreased, confirming successful functionalization. Drug loading capacity increased markedly from 22.5% (LP-SBA-15) to 62.5% (LPSBA-15-TBA). Release studies showed that unmodified LP-SBA-15 exhibited a rapid initial burst, whereas the TBA-functionalized material exhibited a gradual and sustained release. Kinetic fitting indicated a diffusion-controlled mechanism. LP-SBA-15-TBA proved to be a robust platform for loratadine delivery, combining high drug loading with sustained release. This strategy could improvetherapeutic efficacy, reduce dosing frequency, and enhance patient compliance.
Fil: Juárez, Juliana. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Gómez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Peer Reviewed
Fuente
REVISTA DE CIENCIA DE MATERIALES, vol. 61 (págs. 2960-2974)
Materia
Loratadine
LP-SBA-15
TBA
Drug delivery
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Attribution-NonCommercial-NoDerivs 2.5 Argentina
Repositorio
Repositorio Institucional Abierto (UTN)
Institución
Universidad Tecnológica Nacional
OAI Identificador
oai:ria.utn.edu.ar:20.500.12272/15512
Acceder
id RIAUTN_88e8050bb5cc502fc4d9a883108d22bb
oai_identifier_str oai:ria.utn.edu.ar:20.500.12272/15512
network_acronym_str RIAUTN
repository_id_str a
network_name_str Repositorio Institucional Abierto (UTN)
spelling Functional LP-SBA-15/tert-butylamine nanocarriers for loratadine: synthesis, characterization, and controlled release evaluationJuárez, JulianaCussa , jorgelinaGómez Costa, Marcos BrunoLoratadineLP-SBA-15TBADrug deliveryThe development of functional mesoporous carriers offers a promising strategy for enhancing the solubility and controlled release of poorly water-soluble drugs. This study aims to design and evaluate tert-butylamine-functionalized large-pore SBA-15 (LP-SBA-15) as an efficient carrier for loratadine (LORA). LP-SBA-15 was synthesized using a micelle-expanding agent and subsequently functionalized with TBA groups. Structural integrity and chemical modifications were confirmed through XRD, TEM, FTIR, and UV–Vis analyses. Nitrogen physisorption was used to assess textural changes after functionalization and drug loading. Drug loading content (DLC) and release profiles were determined spectrophotometrically, and release kinetics were modeled using Ritger–Peppas, Higuchi, and Weibull equations. The mesostructure was preserved after modification, while surface area and pore volume decreased, confirming successful functionalization. Drug loading capacity increased markedly from 22.5% (LP-SBA-15) to 62.5% (LPSBA-15-TBA). Release studies showed that unmodified LP-SBA-15 exhibited a rapid initial burst, whereas the TBA-functionalized material exhibited a gradual and sustained release. Kinetic fitting indicated a diffusion-controlled mechanism. LP-SBA-15-TBA proved to be a robust platform for loratadine delivery, combining high drug loading with sustained release. This strategy could improvetherapeutic efficacy, reduce dosing frequency, and enhance patient compliance.Fil: Juárez, Juliana. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.Fil: Gómez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.Peer ReviewedSALTADOR2026-09-10T19:51:48Z2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articulopdfapplication/pdfREVISTA DE CIENCIA DE MATERIALES, vol. 61 (págs. 2960-2974) - ISSN 0022-2461 SPRINGER0022-2461https://hdl.handle.net/20.500.12272/15512REVISTA DE CIENCIA DE MATERIALES, vol. 61 (págs. 2960-2974)reponame:Repositorio Institucional Abierto (UTN)instname:Universidad Tecnológica Nacionalenginfo:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivs 2.5 Argentinahttp://creativecommons.org/licenses/by-nc-nd/2.5/ar/JUAREZ, JULIANA ; CUSSA, JORGELINA ; GOMEZ COSTA, MARCOS BRUNOhttps://creativecommons.org/licenses/by-nc-nd/4.0/2026-09-24T12:44:13Zoai:ria.utn.edu.ar:20.500.12272/15512instacron:UTNInstitucionalhttp://ria.utn.edu.ar/Universidad públicaNo correspondehttp://ria.utn.edu.ar/oaigestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2026-09-24 12:44:14.457Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacionalfalse
dc.title.none.fl_str_mv Functional LP-SBA-15/tert-butylamine nanocarriers for loratadine: synthesis, characterization, and controlled release evaluation
title Functional LP-SBA-15/tert-butylamine nanocarriers for loratadine: synthesis, characterization, and controlled release evaluation
spellingShingle Functional LP-SBA-15/tert-butylamine nanocarriers for loratadine: synthesis, characterization, and controlled release evaluation
Juárez, Juliana
Loratadine
LP-SBA-15
TBA
Drug delivery
title_short Functional LP-SBA-15/tert-butylamine nanocarriers for loratadine: synthesis, characterization, and controlled release evaluation
title_full Functional LP-SBA-15/tert-butylamine nanocarriers for loratadine: synthesis, characterization, and controlled release evaluation
title_fullStr Functional LP-SBA-15/tert-butylamine nanocarriers for loratadine: synthesis, characterization, and controlled release evaluation
title_full_unstemmed Functional LP-SBA-15/tert-butylamine nanocarriers for loratadine: synthesis, characterization, and controlled release evaluation
title_sort Functional LP-SBA-15/tert-butylamine nanocarriers for loratadine: synthesis, characterization, and controlled release evaluation
dc.creator.none.fl_str_mv Juárez, Juliana
Cussa , jorgelina
Gómez Costa, Marcos Bruno
author Juárez, Juliana
author_facet Juárez, Juliana
Cussa , jorgelina
Gómez Costa, Marcos Bruno
author_role author
author2 Cussa , jorgelina
Gómez Costa, Marcos Bruno
author2_role author
author
dc.subject.none.fl_str_mv Loratadine
LP-SBA-15
TBA
Drug delivery
topic Loratadine
LP-SBA-15
TBA
Drug delivery
dc.description.none.fl_txt_mv The development of functional mesoporous carriers offers a promising strategy for enhancing the solubility and controlled release of poorly water-soluble drugs. This study aims to design and evaluate tert-butylamine-functionalized large-pore SBA-15 (LP-SBA-15) as an efficient carrier for loratadine (LORA). LP-SBA-15 was synthesized using a micelle-expanding agent and subsequently functionalized with TBA groups. Structural integrity and chemical modifications were confirmed through XRD, TEM, FTIR, and UV–Vis analyses. Nitrogen physisorption was used to assess textural changes after functionalization and drug loading. Drug loading content (DLC) and release profiles were determined spectrophotometrically, and release kinetics were modeled using Ritger–Peppas, Higuchi, and Weibull equations. The mesostructure was preserved after modification, while surface area and pore volume decreased, confirming successful functionalization. Drug loading capacity increased markedly from 22.5% (LP-SBA-15) to 62.5% (LPSBA-15-TBA). Release studies showed that unmodified LP-SBA-15 exhibited a rapid initial burst, whereas the TBA-functionalized material exhibited a gradual and sustained release. Kinetic fitting indicated a diffusion-controlled mechanism. LP-SBA-15-TBA proved to be a robust platform for loratadine delivery, combining high drug loading with sustained release. This strategy could improvetherapeutic efficacy, reduce dosing frequency, and enhance patient compliance.
Fil: Juárez, Juliana. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Gómez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Peer Reviewed
description The development of functional mesoporous carriers offers a promising strategy for enhancing the solubility and controlled release of poorly water-soluble drugs. This study aims to design and evaluate tert-butylamine-functionalized large-pore SBA-15 (LP-SBA-15) as an efficient carrier for loratadine (LORA). LP-SBA-15 was synthesized using a micelle-expanding agent and subsequently functionalized with TBA groups. Structural integrity and chemical modifications were confirmed through XRD, TEM, FTIR, and UV–Vis analyses. Nitrogen physisorption was used to assess textural changes after functionalization and drug loading. Drug loading content (DLC) and release profiles were determined spectrophotometrically, and release kinetics were modeled using Ritger–Peppas, Higuchi, and Weibull equations. The mesostructure was preserved after modification, while surface area and pore volume decreased, confirming successful functionalization. Drug loading capacity increased markedly from 22.5% (LP-SBA-15) to 62.5% (LPSBA-15-TBA). Release studies showed that unmodified LP-SBA-15 exhibited a rapid initial burst, whereas the TBA-functionalized material exhibited a gradual and sustained release. Kinetic fitting indicated a diffusion-controlled mechanism. LP-SBA-15-TBA proved to be a robust platform for loratadine delivery, combining high drug loading with sustained release. This strategy could improvetherapeutic efficacy, reduce dosing frequency, and enhance patient compliance.
publishDate 2025
dc.date.none.fl_str_mv 2025
2026-09-10T19:51:48Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv REVISTA DE CIENCIA DE MATERIALES, vol. 61 (págs. 2960-2974) - ISSN 0022-2461 SPRINGER
0022-2461
https://hdl.handle.net/20.500.12272/15512
identifier_str_mv REVISTA DE CIENCIA DE MATERIALES, vol. 61 (págs. 2960-2974) - ISSN 0022-2461 SPRINGER
0022-2461
url https://hdl.handle.net/20.500.12272/15512
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivs 2.5 Argentina
http://creativecommons.org/licenses/by-nc-nd/2.5/ar/
JUAREZ, JULIANA ; CUSSA, JORGELINA ; GOMEZ COSTA, MARCOS BRUNO
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivs 2.5 Argentina
http://creativecommons.org/licenses/by-nc-nd/2.5/ar/
JUAREZ, JULIANA ; CUSSA, JORGELINA ; GOMEZ COSTA, MARCOS BRUNO
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv pdf
application/pdf
dc.publisher.none.fl_str_mv SALTADOR
publisher.none.fl_str_mv SALTADOR
dc.source.none.fl_str_mv REVISTA DE CIENCIA DE MATERIALES, vol. 61 (págs. 2960-2974)
reponame:Repositorio Institucional Abierto (UTN)
instname:Universidad Tecnológica Nacional
reponame_str Repositorio Institucional Abierto (UTN)
collection Repositorio Institucional Abierto (UTN)
instname_str Universidad Tecnológica Nacional
repository.name.fl_str_mv Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacional
repository.mail.fl_str_mv gestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.ar
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score 13.24418

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