Incorporation and drug delivery of sodium indomethacin into nanoclays

Autores
Mendieta, Silvia Nazaret; Gerbaldo, María Verónica; Pérez, Celso; Longhi, Marcela; Granero, Gladys Ester; Crivello, Mónica Elsie
Año de publicación
2016
Idioma
español castellano
Tipo de recurso
documento de conferencia
Estado
versión borrador
Descripción
Layered double hydroxides (LDH) nanoclays have many applications as matrices in pharmaceutical fields as support for controlled release systems of drugs, vitamins, biomolecules, etc. γ-Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain involved in osteoarthritis, rheumatoid arthritis, bursitis, gout, etc. This work reported studies of intercalation and release of nanoclay MgAl LDH-type material containing the anionic form of indomethacin in the interlayer region, starting from sodium indomethacin (IndoNa). Sodium Indomethacin hydrate was obtained by co-precipitation of Na2CO3 and the polymorph of indomethacin was observed. Intercalated compound was prepared via ion exchange, with different incorporation time. The host laminar solid was prepared by coprecipitation of Mg-Al salts at pH 10±0.2; on N2 atmosphere, and different aging time. By X-ray diffraction was observed the drug incorporation into nanoclay. The basal spacing obtained suggests that the drugs molecules are arranged in partially interdigitated bilayers and multiple arrangements were observed. The amount of intercalated IndoNa was determined by UV-visible spectroscopy. The host with less aging and ion exchange time presented a greater incorporation. Drug release studies were performed at 37.0±0.5 °C in dissolution media simulated, intestinal fluids at pH 7.4±0.05. The maximum release was 72 % for LDH-S, but none guest solid does not release more than 85% due to the strong interaction with the brucite layer. LHD-L has a longer aging and better layer structure resulting in reduced incorporation. This behavior determines the release time. This work provides significant in-sight into the important area of storage, transport, and delivering of anionic drug over time using MgAl-LDH as a drug delivery.
Fil: Crivello, Mónica Elsie. Centro de Investigación y Tecnología Química. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad Tecnológica Nacional. Facultad Regional Córdoba; Argentina.
Fil: Mendieta, Silvia Nazaret. Centro de Investigación y Tecnología Química. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad Tecnológica Nacional. Facultad Regional Córdoba; Argentina.
Fil: Gerbaldo, María Verónica. Centro de Investigación y Tecnología Química. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad Tecnológica Nacional. Facultad Regional Córdoba; Argentina.
Fil: Pérez, Celso. Centro de Investigación y Tecnología Química. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad Tecnológica Nacional. Facultad Regional Córdoba; Argentina.
Fil: Granero, Gladys Ester. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica . CONICET. Universidad Nacional de Córdoba; Argentina.
Fil: Longhi, Marcela. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica . CONICET. Universidad Nacional de Córdoba; Argentina.
Materia
nanoclay
sodium indomethacin
drug delivery
Nivel de accesibilidad
acceso abierto
Condiciones de uso
2022-05-30T22:28:04Z
Repositorio
Repositorio Institucional Abierto (UTN)
Institución
Universidad Tecnológica Nacional
OAI Identificador
oai:ria.utn.edu.ar:20.500.12272/6548
Acceder
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network_acronym_str RIAUTN
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network_name_str Repositorio Institucional Abierto (UTN)
spelling Incorporation and drug delivery of sodium indomethacin into nanoclaysMendieta, Silvia NazaretGerbaldo, María VerónicaPérez, CelsoLonghi, MarcelaGranero, Gladys EsterCrivello, Mónica Elsienanoclaysodium indomethacindrug deliveryLayered double hydroxides (LDH) nanoclays have many applications as matrices in pharmaceutical fields as support for controlled release systems of drugs, vitamins, biomolecules, etc. γ-Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain involved in osteoarthritis, rheumatoid arthritis, bursitis, gout, etc. This work reported studies of intercalation and release of nanoclay MgAl LDH-type material containing the anionic form of indomethacin in the interlayer region, starting from sodium indomethacin (IndoNa). Sodium Indomethacin hydrate was obtained by co-precipitation of Na2CO3 and the polymorph of indomethacin was observed. Intercalated compound was prepared via ion exchange, with different incorporation time. The host laminar solid was prepared by coprecipitation of Mg-Al salts at pH 10±0.2; on N2 atmosphere, and different aging time. By X-ray diffraction was observed the drug incorporation into nanoclay. The basal spacing obtained suggests that the drugs molecules are arranged in partially interdigitated bilayers and multiple arrangements were observed. The amount of intercalated IndoNa was determined by UV-visible spectroscopy. The host with less aging and ion exchange time presented a greater incorporation. Drug release studies were performed at 37.0±0.5 °C in dissolution media simulated, intestinal fluids at pH 7.4±0.05. The maximum release was 72 % for LDH-S, but none guest solid does not release more than 85% due to the strong interaction with the brucite layer. LHD-L has a longer aging and better layer structure resulting in reduced incorporation. This behavior determines the release time. This work provides significant in-sight into the important area of storage, transport, and delivering of anionic drug over time using MgAl-LDH as a drug delivery.Fil: Crivello, Mónica Elsie. Centro de Investigación y Tecnología Química. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad Tecnológica Nacional. Facultad Regional Córdoba; Argentina.Fil: Mendieta, Silvia Nazaret. Centro de Investigación y Tecnología Química. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad Tecnológica Nacional. Facultad Regional Córdoba; Argentina.Fil: Gerbaldo, María Verónica. Centro de Investigación y Tecnología Química. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad Tecnológica Nacional. Facultad Regional Córdoba; Argentina.Fil: Pérez, Celso. Centro de Investigación y Tecnología Química. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad Tecnológica Nacional. Facultad Regional Córdoba; Argentina.Fil: Granero, Gladys Ester. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica . CONICET. Universidad Nacional de Córdoba; Argentina.Fil: Longhi, Marcela. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica . CONICET. Universidad Nacional de Córdoba; Argentina.2022-05-30T22:28:04Z2022-05-30T22:28:04Z2016info:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/drafthttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciapdfapplication/pdfhttp://hdl.handle.net/20.500.12272/6548-spainfo:eu-repo/semantics/openAccess2022-05-30T22:28:04Zhttp://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 InternacionalCrivello, Mónica ElsieX Atribución (Attribution): En cualquier explotación de la obra autorizada por la licencia será necesario reconocer la autoría (obligatoria en todos los casos). X No comercial (Non Commercial): La explotación de la obra queda limitada a usos no comerciales. X Sin obras derivadas (No Derivate Works): La autorización para explotar la obra no incluye la posibilidad de crear una obra derivada (traducciones, adaptaciones, etc.). X Compartir igual (Share Alike): La explotación autorizada incluye la creación de obras derivadas siempre que se mantenga la misma licencia al ser divulgadas.reponame:Repositorio Institucional Abierto (UTN)instname:Universidad Tecnológica Nacional2026-10-01T11:57:17Zoai:ria.utn.edu.ar:20.500.12272/6548instacron:UTNInstitucionalhttp://ria.utn.edu.ar/Universidad públicaNo correspondehttp://ria.utn.edu.ar/oaigestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2026-10-01 11:57:18.179Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacionalfalse
dc.title.none.fl_str_mv Incorporation and drug delivery of sodium indomethacin into nanoclays
title Incorporation and drug delivery of sodium indomethacin into nanoclays
spellingShingle Incorporation and drug delivery of sodium indomethacin into nanoclays
Mendieta, Silvia Nazaret
nanoclay
sodium indomethacin
drug delivery
title_short Incorporation and drug delivery of sodium indomethacin into nanoclays
title_full Incorporation and drug delivery of sodium indomethacin into nanoclays
title_fullStr Incorporation and drug delivery of sodium indomethacin into nanoclays
title_full_unstemmed Incorporation and drug delivery of sodium indomethacin into nanoclays
title_sort Incorporation and drug delivery of sodium indomethacin into nanoclays
dc.creator.none.fl_str_mv Mendieta, Silvia Nazaret
Gerbaldo, María Verónica
Pérez, Celso
Longhi, Marcela
Granero, Gladys Ester
Crivello, Mónica Elsie
author Mendieta, Silvia Nazaret
author_facet Mendieta, Silvia Nazaret
Gerbaldo, María Verónica
Pérez, Celso
Longhi, Marcela
Granero, Gladys Ester
Crivello, Mónica Elsie
author_role author
author2 Gerbaldo, María Verónica
Pérez, Celso
Longhi, Marcela
Granero, Gladys Ester
Crivello, Mónica Elsie
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv nanoclay
sodium indomethacin
drug delivery
topic nanoclay
sodium indomethacin
drug delivery
dc.description.none.fl_txt_mv Layered double hydroxides (LDH) nanoclays have many applications as matrices in pharmaceutical fields as support for controlled release systems of drugs, vitamins, biomolecules, etc. γ-Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain involved in osteoarthritis, rheumatoid arthritis, bursitis, gout, etc. This work reported studies of intercalation and release of nanoclay MgAl LDH-type material containing the anionic form of indomethacin in the interlayer region, starting from sodium indomethacin (IndoNa). Sodium Indomethacin hydrate was obtained by co-precipitation of Na2CO3 and the polymorph of indomethacin was observed. Intercalated compound was prepared via ion exchange, with different incorporation time. The host laminar solid was prepared by coprecipitation of Mg-Al salts at pH 10±0.2; on N2 atmosphere, and different aging time. By X-ray diffraction was observed the drug incorporation into nanoclay. The basal spacing obtained suggests that the drugs molecules are arranged in partially interdigitated bilayers and multiple arrangements were observed. The amount of intercalated IndoNa was determined by UV-visible spectroscopy. The host with less aging and ion exchange time presented a greater incorporation. Drug release studies were performed at 37.0±0.5 °C in dissolution media simulated, intestinal fluids at pH 7.4±0.05. The maximum release was 72 % for LDH-S, but none guest solid does not release more than 85% due to the strong interaction with the brucite layer. LHD-L has a longer aging and better layer structure resulting in reduced incorporation. This behavior determines the release time. This work provides significant in-sight into the important area of storage, transport, and delivering of anionic drug over time using MgAl-LDH as a drug delivery.
Fil: Crivello, Mónica Elsie. Centro de Investigación y Tecnología Química. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad Tecnológica Nacional. Facultad Regional Córdoba; Argentina.
Fil: Mendieta, Silvia Nazaret. Centro de Investigación y Tecnología Química. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad Tecnológica Nacional. Facultad Regional Córdoba; Argentina.
Fil: Gerbaldo, María Verónica. Centro de Investigación y Tecnología Química. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad Tecnológica Nacional. Facultad Regional Córdoba; Argentina.
Fil: Pérez, Celso. Centro de Investigación y Tecnología Química. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad Tecnológica Nacional. Facultad Regional Córdoba; Argentina.
Fil: Granero, Gladys Ester. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica . CONICET. Universidad Nacional de Córdoba; Argentina.
Fil: Longhi, Marcela. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica . CONICET. Universidad Nacional de Córdoba; Argentina.
description Layered double hydroxides (LDH) nanoclays have many applications as matrices in pharmaceutical fields as support for controlled release systems of drugs, vitamins, biomolecules, etc. γ-Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain involved in osteoarthritis, rheumatoid arthritis, bursitis, gout, etc. This work reported studies of intercalation and release of nanoclay MgAl LDH-type material containing the anionic form of indomethacin in the interlayer region, starting from sodium indomethacin (IndoNa). Sodium Indomethacin hydrate was obtained by co-precipitation of Na2CO3 and the polymorph of indomethacin was observed. Intercalated compound was prepared via ion exchange, with different incorporation time. The host laminar solid was prepared by coprecipitation of Mg-Al salts at pH 10±0.2; on N2 atmosphere, and different aging time. By X-ray diffraction was observed the drug incorporation into nanoclay. The basal spacing obtained suggests that the drugs molecules are arranged in partially interdigitated bilayers and multiple arrangements were observed. The amount of intercalated IndoNa was determined by UV-visible spectroscopy. The host with less aging and ion exchange time presented a greater incorporation. Drug release studies were performed at 37.0±0.5 °C in dissolution media simulated, intestinal fluids at pH 7.4±0.05. The maximum release was 72 % for LDH-S, but none guest solid does not release more than 85% due to the strong interaction with the brucite layer. LHD-L has a longer aging and better layer structure resulting in reduced incorporation. This behavior determines the release time. This work provides significant in-sight into the important area of storage, transport, and delivering of anionic drug over time using MgAl-LDH as a drug delivery.
publishDate 2016
dc.date.none.fl_str_mv 2016
2022-05-30T22:28:04Z
2022-05-30T22:28:04Z
dc.type.none.fl_str_mv info:eu-repo/semantics/conferenceObject
info:eu-repo/semantics/draft
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dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12272/6548
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url http://hdl.handle.net/20.500.12272/6548
identifier_str_mv -
dc.language.none.fl_str_mv spa
language spa
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
2022-05-30T22:28:04Z
http://creativecommons.org/licenses/by-nc-nd/4.0/
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Crivello, Mónica Elsie
X Atribución (Attribution): En cualquier explotación de la obra autorizada por la licencia será necesario reconocer la autoría (obligatoria en todos los casos). X No comercial (Non Commercial): La explotación de la obra queda limitada a usos no comerciales. X Sin obras derivadas (No Derivate Works): La autorización para explotar la obra no incluye la posibilidad de crear una obra derivada (traducciones, adaptaciones, etc.). X Compartir igual (Share Alike): La explotación autorizada incluye la creación de obras derivadas siempre que se mantenga la misma licencia al ser divulgadas.
eu_rights_str_mv openAccess
rights_invalid_str_mv 2022-05-30T22:28:04Z
http://creativecommons.org/licenses/by-nc-nd/4.0/
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Crivello, Mónica Elsie
X Atribución (Attribution): En cualquier explotación de la obra autorizada por la licencia será necesario reconocer la autoría (obligatoria en todos los casos). X No comercial (Non Commercial): La explotación de la obra queda limitada a usos no comerciales. X Sin obras derivadas (No Derivate Works): La autorización para explotar la obra no incluye la posibilidad de crear una obra derivada (traducciones, adaptaciones, etc.). X Compartir igual (Share Alike): La explotación autorizada incluye la creación de obras derivadas siempre que se mantenga la misma licencia al ser divulgadas.
dc.format.none.fl_str_mv pdf
application/pdf
dc.source.none.fl_str_mv reponame:Repositorio Institucional Abierto (UTN)
instname:Universidad Tecnológica Nacional
reponame_str Repositorio Institucional Abierto (UTN)
collection Repositorio Institucional Abierto (UTN)
instname_str Universidad Tecnológica Nacional
repository.name.fl_str_mv Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacional
repository.mail.fl_str_mv gestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.ar
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